| Tissue Specificity | Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain. |
| Function | Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. |
| Protein Name | Pyruvate DehydrogenaseAcetyl-Transferring Kinase Isozyme 3 - MitochondrialPyruvate Dehydrogenase Kinase Isoform 3 |
| Database Links | Reactome: R-HSA-204174Reactome: R-HSA-5362517 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Pyruvate Dehydrogenase antibodyAnti-Acetyl-Transferring Kinase Isozyme 3 - Mitochondrial antibodyAnti-Pyruvate Dehydrogenase Kinase Isoform 3 antibodyAnti-PDK3 antibodyAnti-PDHK3 antibody |
Information sourced from Uniprot.org
