| Post Translational Modifications | Within the major histocompatibility complex class I (MHC I) peptide loading complex forms reversible disulfide-linked heterodimers with TAPBP as part of its protein folding chaperone activity. This is essential to assist the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Phosphorylated. |
| Function | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity. |
| Protein Name | Protein Disulfide-Isomerase A358 Kda Glucose-Regulated Protein58 Kda Microsomal ProteinP58Disulfide Isomerase Er-60Endoplasmic Reticulum Resident Protein 57Er Protein 57Erp57Endoplasmic Reticulum Resident Protein 60Er Protein 60Erp60 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-901042Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic ReticulumEndoplasmic Reticulum LumenMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Protein Disulfide-Isomerase A3 antibodyAnti-58 Kda Glucose-Regulated Protein antibodyAnti-58 Kda Microsomal Protein antibodyAnti-P58 antibodyAnti-Disulfide Isomerase Er-60 antibodyAnti-Endoplasmic Reticulum Resident Protein 57 antibodyAnti-Er Protein 57 antibodyAnti-Erp57 antibodyAnti-Endoplasmic Reticulum Resident Protein 60 antibodyAnti-Er Protein 60 antibodyAnti-Erp60 antibodyAnti-PDIA3 antibodyAnti-ERP57 antibodyAnti-ERP60 antibodyAnti-GRP58 antibody |
Information sourced from Uniprot.org
