| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDE8B |
| Gene ID: | 8622 |
| Uniprot ID: | PDE8B_HUMAN |
| Immunogen Region: | 1-210 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PDE8B (NP_003710.1). |
| Immunogen Sequence: | MGCAPSIHVSQSGVIYCRDS DESSSPRQTTSVSQGPAAPL PGLFVQTDAADAIPPSRASG PPSVARVRRARTELGSGSSA GSAAPAATTSRGRRRHCCSS AEAETQTCYTSVKQVSSAEV RIGPMRLTQDPIQVLLIFAK EDSQSDGFWWACDRAGYRCN IARTPESALECFLDKHHEII VIDHRQTQNFDAEAVCRSIR ATNPSEHTVI |
| Tissue Specificity | Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates. |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. |
| Protein Name | High Affinity Camp-Specific And Ibmx-Insensitive 3' -5'-Cyclic Phosphodiesterase 8bHspde8bCell Proliferation-Inducing Gene 22 Protein |
| Database Links | Reactome: R-HSA-418555 |
| Alternative Antibody Names | Anti-High Affinity Camp-Specific And Ibmx-Insensitive 3' -5'-Cyclic Phosphodiesterase 8b antibodyAnti-Hspde8b antibodyAnti-Cell Proliferation-Inducing Gene 22 Protein antibodyAnti-PDE8B antibodyAnti-PIG22 antibody |
Information sourced from Uniprot.org