| Tissue Specificity | Present at high level in Sertoli cells, but not detected in spermatogenic cells (at protein level). Low expression in spleen, thymus and prostate. |
| Function | Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD. Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD. |
| Protein Name | Spermatogenesis-Associated Protein 2 |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956 |
| Cellular Localisation | CytoplasmNucleusDetected In The Tubular Compartment Of The Testis AndIn The Cytoplasm Of The Sertoli Cells |
| Alternative Antibody Names | Anti-Spermatogenesis-Associated Protein 2 antibodyAnti-SPATA2 antibodyAnti-KIAA0757 antibodyAnti-PD1 antibody |
Information sourced from Uniprot.org
![Anti-PD1 antibody [NAT105] (STJ16100414)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149131/346752/STJ16100414_1__96545.1681998848.jpg?c=1 "Anti-PD1 antibody [NAT105] (STJ16100414)")
![Anti-PD1 antibody [NAT105] (STJ16100414)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149131/346752/STJ16100414_1__96545.1681998848.jpg?c=1 "Anti-PD1 antibody [NAT105] (STJ16100414)")
