| Host: | Mouse |
| Applications: | WB/IHC/IF |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Paired box protein Pax-5 (150-250 aa) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ABT-PAX5 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2bk |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-500WB 1:100-2000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PAX5 |
| Gene ID: | 5079 |
| Uniprot ID: | PAX5_HUMAN |
| Immunogen Region: | 150-250 aa |
| Specificity: | This antibody detects endogenous levels of human B-Cell-Specific Activator Protein (PAX-5). Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH9.0 was highly recommended as antigen repair method in p |
| Immunogen: | Synthesized peptide derived from the human B-Cell-Specific Activator Protein (PAX-5) at the amino acid range 150-250 |
| Function | Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire. (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription. Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity. |
| Protein Name | Paired Box Protein Pax-5B-Cell-Specific Transcription FactorBsap |
| Database Links | Reactome: R-HSA-8939245 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paired Box Protein Pax-5 antibodyAnti-B-Cell-Specific Transcription Factor antibodyAnti-Bsap antibodyAnti-PAX5 antibody |
Information sourced from Uniprot.org