| Function | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1. Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation. Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation. |
| Protein Name | Terminal Nucleotidyltransferase 4bNon-Canonical Poly(A Rna Polymerase Papd5Pap-Associated Domain-Containing Protein 5Terminal GuanylyltransferaseTerminal Uridylyltransferase 3Tutase 3Topoisomerase-Related Function Protein 4-2Trf4-2 |
| Cellular Localisation | NucleusNucleolusCytoplasmPredominantly Expressed In The Cytoplasm |
| Alternative Antibody Names | Anti-Terminal Nucleotidyltransferase 4b antibodyAnti-Non-Canonical Poly(A Rna Polymerase Papd5 antibodyAnti-Pap-Associated Domain-Containing Protein 5 antibodyAnti-Terminal Guanylyltransferase antibodyAnti-Terminal Uridylyltransferase 3 antibodyAnti-Tutase 3 antibodyAnti-Topoisomerase-Related Function Protein 4-2 antibodyAnti-Trf4-2 antibodyAnti-TENT4B antibodyAnti-GLD4 antibodyAnti-PAPD5 antibodyAnti-TRF4-2 antibodyAnti-TUT3 antibody |
Information sourced from Uniprot.org
