| Function | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. |
| Protein Name | Pan2-Pan3 Deadenylation Complex Catalytic Subunit Pan2Inactive Ubiquitin Carboxyl-Terminal Hydrolase 52Pab1p-Dependent Poly(A-Specific RibonucleasePoly(A-Nuclease Deadenylation Complex Subunit 2Pan Deadenylation Complex Subunit 2 |
| Database Links | Reactome: R-HSA-429947 |
| Cellular Localisation | CytoplasmP-BodyNucleusShuttles Between Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Pan2-Pan3 Deadenylation Complex Catalytic Subunit Pan2 antibodyAnti-Inactive Ubiquitin Carboxyl-Terminal Hydrolase 52 antibodyAnti-Pab1p-Dependent Poly(A-Specific Ribonuclease antibodyAnti-Poly(A-Nuclease Deadenylation Complex Subunit 2 antibodyAnti-Pan Deadenylation Complex Subunit 2 antibodyAnti-PAN2 antibodyAnti-KIAA0710 antibodyAnti-USP52 antibody |
Information sourced from Uniprot.org
