| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAN2 (700-1000) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAN2 |
| Gene ID: |
9924 |
| Uniprot ID: |
PAN2_HUMAN |
| Immunogen Region: |
700-1000 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human PAN2 (NP_001120932.1). |
| Immunogen Sequence: |
DFAQVLKRSICLDQNTQAWC DTCEKYQPTIQTRNIRHLPD ILVINCEVNSSKEADFWRMQ AEVAFKMAVKKHGGEISKNK EFALADWKELGSPEGVLVCP SIEELKNVWLPFSIRMKMTK NKGLDVCNWTDGDEMQWGPA RAEEEHGVYVYDLMATVVHI LDSRTGGSLVAHIKVGETYH QRKEGVTHQQWYLFNDFLIE PIDKHEAVQFDMNWKVPAIL YYVKRNLNSRYNLNIKNPI |
| Function | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. |
| Protein Name | Pan2-Pan3 Deadenylation Complex Catalytic Subunit Pan2Inactive Ubiquitin Carboxyl-Terminal Hydrolase 52Pab1p-Dependent Poly(A-Specific RibonucleasePoly(A-Nuclease Deadenylation Complex Subunit 2Pan Deadenylation Complex Subunit 2 |
| Database Links | Reactome: R-HSA-429947 |
| Cellular Localisation | CytoplasmP-BodyNucleusShuttles Between Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Pan2-Pan3 Deadenylation Complex Catalytic Subunit Pan2 antibodyAnti-Inactive Ubiquitin Carboxyl-Terminal Hydrolase 52 antibodyAnti-Pab1p-Dependent Poly(A-Specific Ribonuclease antibodyAnti-Poly(A-Nuclease Deadenylation Complex Subunit 2 antibodyAnti-Pan Deadenylation Complex Subunit 2 antibodyAnti-PAN2 antibodyAnti-KIAA0710 antibodyAnti-USP52 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
