| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
P2RX1 |
| Gene ID: |
5023 |
| Uniprot ID: |
P2RX1_HUMAN |
| Immunogen Region: |
51-330 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 51-330 of human P2RX1 (NP_002549.1). |
| Immunogen Sequence: |
YEKGYQTSSGLISSVSVKLK GLAVTQLPGLGPQVWDVADY VFPAQGDNSFVVMTNFIVTP KQTQGYCAEHPEGGICKEDS GCTPGKAKRKAQGIRTGKCV AFNDTVKTCEIFGWCPVEVD DDIPRPALLREAENFTLFIK NSISFPRFKVNRRNLVEEVN AAHMKTCLFHKTLHPLCPVF QLGYVVQESGQNFSTLAEKG GVVGITIDWHCDLDWHVRHC RPIYEFHGLYEEKNLSPGF |
| Tissue Specificity | Expressed on neutrophils and platelets. Expressed on urinary bladder smooth muscle. |
| Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability. Furthermore, CTP functions as a weak affinity agonist for P2RX1. Plays a role a role in urogenital, immune and cardiovascular function. Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function. In addition, contributes to smooth muscle contractions of the urinary bladder. On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis. On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells. |
| Protein Name | P2x Purinoceptor 1P2x1Atp ReceptorPurinergic Receptor |
| Database Links | Reactome: R-HSA-139853Reactome: R-HSA-418346Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinDetected At Plasma Membrane Lipid Rafts |
| Alternative Antibody Names | Anti-P2x Purinoceptor 1 antibodyAnti-P2x1 antibodyAnti-Atp Receptor antibodyAnti-Purinergic Receptor antibodyAnti-P2RX1 antibodyAnti-P2X1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
