Anti-OTUD3 antibody (STJ11106339)

SKU:
STJ11106339

£112.50 - £524.50
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: OTUD3
Gene ID: 23252
Uniprot ID: OTUD3_HUMAN
Specificity: Recombinant protein of human OTUD3.
Post Translational Modifications Glucose and fatty acids stimulate CREBBP-dependent acetylation, promoting its nuclear translocation.
Function Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination.
Protein Name Otu Domain-Containing Protein 3
Database Links Reactome: R-HSA-5689896
Reactome: R-HSA-8948751
Cellular Localisation Cytoplasm
Nucleus
Glucose Or Fatty Acid Promote Nuclear Translocation Upon Acetylation
Alternative Antibody Names Anti-Otu Domain-Containing Protein 3 antibody
Anti-OTUD3 antibody
Anti-KIAA0459 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance