| Post Translational Modifications | Glucose and fatty acids stimulate CREBBP-dependent acetylation, promoting its nuclear translocation. |
| Function | Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. |
| Protein Name | Otu Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-5689896Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmNucleusGlucose Or Fatty Acid Promote Nuclear Translocation Upon Acetylation |
| Alternative Antibody Names | Anti-Otu Domain-Containing Protein 3 antibodyAnti-OTUD3 antibodyAnti-KIAA0459 antibody |
Information sourced from Uniprot.org
