| Tissue Specificity | Ubiquitously expressed. |
| Function | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol. |
| Protein Name | Oxysterol-Binding Protein-Related Protein 5Orp-5Osbp-Related Protein 5Oxysterol-Binding Protein Homolog 1 |
| Database Links | Reactome: R-HSA-1482801 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinLocalizes To Endoplasmic Reticulum-Plasma Membrane Contact Sites (Epcs)Localizes To The Cortical Endoplasmic Reticulum At The Epcs |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 5 antibodyAnti-Orp-5 antibodyAnti-Osbp-Related Protein 5 antibodyAnti-Oxysterol-Binding Protein Homolog 1 antibodyAnti-OSBPL5 antibodyAnti-KIAA1534 antibodyAnti-OBPH1 antibodyAnti-ORP5 antibody |
Information sourced from Uniprot.org
