| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADP-ribose glycohydrolase OARD1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OARD1 |
| Gene ID: |
221443 |
| Uniprot ID: |
OARD1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of C6orf130 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human C6orf130 |
| Function | ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively. |
| Protein Name | Adp-Ribose Glycohydrolase Oard1O-Acetyl-Adp-Ribose Deacetylase 1Terminal Adp-Ribose Protein Glycohydrolase 1Protein Adp-Ribosylglutamate Hydrolase Oard1 |
| Cellular Localisation | NucleusNucleoplasmNucleolusChromosomeLocalizes Both In The Nucleoplasm And In The NucleolusRelocalizes To The Nucleoplasm In Response To Dna DamageRecruited To Dna Lesion Regions Following Dna Damage |
| Alternative Antibody Names | Anti-Adp-Ribose Glycohydrolase Oard1 antibodyAnti-O-Acetyl-Adp-Ribose Deacetylase 1 antibodyAnti-Terminal Adp-Ribose Protein Glycohydrolase 1 antibodyAnti-Protein Adp-Ribosylglutamate Hydrolase Oard1 antibodyAnti-OARD1 antibodyAnti-C6orf130 antibodyAnti-TARG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
