| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NVL |
| Gene ID: | 4931 |
| Uniprot ID: | NVL_HUMAN |
| Immunogen Region: | 340-520 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 340-520 of human NVL (NP_001230076.1). |
| Immunogen Sequence: | CLGIPDEASRERILQTLCRK LRLPQAFDFCHLAHLTPGFV GADLMALCREAAMCAVNRVL MKLQEQQKKNPEMEDLPSKG VQEERLGTEPTSETQDELQR LLGLLRDQDPLSEEQMQGLC IELNDFIVALSSVQPSAKRE GFVTVPNVTWADIGALEDIR EELTMAILAPVRNPDQFKAL G |
| Tissue Specificity | Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina. |
| Function | Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. |
| Protein Name | Nuclear Valosin-Containing Protein-LikeNvlpNuclear Vcp-Like Protein |
| Cellular Localisation | Isoform 2: NucleusNucleoplasmIsoform 1: NucleusNucleolusNucleusExpressed Predominantly In The NucleolusAssociates With Pre-Ribosomal Particles In The Nucleus |
| Alternative Antibody Names | Anti-Nuclear Valosin-Containing Protein-Like antibodyAnti-Nvlp antibodyAnti-Nuclear Vcp-Like Protein antibodyAnti-NVL antibodyAnti-NVL2 antibody |
Information sourced from Uniprot.org