| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUCKS1 |
| Gene ID: | 64710 |
| Uniprot ID: | NUCKS_HUMAN |
| Immunogen Region: | 100-200 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human NUCKS1 (NP_073568.2). |
| Immunogen Sequence: | ASKQREMLMEDVGSEEEQEE EDEAPFQEKDSGSDEDFLME DDDDSDYGSSKKKNKKMVKK SKPERKEKKMPKPRLKATVT PSPVKGKGKVGRPTASKASK E |
| Tissue Specificity | Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung. |
| Post Translational Modifications | Phosphorylated in an ATM-dependent manner in response to DNA damage. Phosphorylated by CDK1 and casein kinase. |
| Function | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1. |
| Protein Name | Nuclear Ubiquitous Casein And Cyclin-Dependent Kinase Substrate 1P1 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Nuclear Ubiquitous Casein And Cyclin-Dependent Kinase Substrate 1 antibodyAnti-P1 antibodyAnti-NUCKS1 antibodyAnti-NUCKS antibodyAnti-JC7 antibody |
Information sourced from Uniprot.org