| Tissue Specificity | Expressed in the blood vessel walls (at protein level). |
| Post Translational Modifications | Proccessed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides. O-glycosylated.contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins. |
| Function | Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response. |
| Protein Name | Neurexin-3-BetaNeurexin Iii-Beta Cleaved Into - Neurexin-3-Beta - Soluble Form - Neurexin-3-Beta - C-Terminal FragmentNrxn3-Ctf |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Presynaptic Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Neurexin-3-Beta antibodyAnti-Neurexin Iii-Beta Cleaved Into - Neurexin-3-Beta - Soluble Form - Neurexin-3-Beta - C-Terminal Fragment antibodyAnti-Nrxn3-Ctf antibodyAnti-NRXN3 antibodyAnti-KIAA0743 antibody |
Information sourced from Uniprot.org
