| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NRCAM (25-115) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NRCAM |
| Gene ID: |
4897 |
| Uniprot ID: |
NRCAM_HUMAN |
| Immunogen Region: |
25-115 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-115 of human NRCAM (Q92823). |
| Immunogen Sequence: |
QMISALEVPLDPKLLEDLVQ PPTITQQSPKDYIIDPRENI VIQCEAKGKPPPSFSWTRNG THFDIDKDPLVTMKPGTGTL IINIMSEGKAE |
| Tissue Specificity | Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus. |
| Function | Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes.not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. |
| Protein Name | Neuronal Cell Adhesion MoleculeNr-CamNeuronal Surface Protein BravoHbravoNgcam-Related Cell Adhesion MoleculeNg-Cam-Related |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-447038Reactome: R-HSA-447043 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonSecretedDetected At Nodes Of Ranvier |
| Alternative Antibody Names | Anti-Neuronal Cell Adhesion Molecule antibodyAnti-Nr-Cam antibodyAnti-Neuronal Surface Protein Bravo antibodyAnti-Hbravo antibodyAnti-Ngcam-Related Cell Adhesion Molecule antibodyAnti-Ng-Cam-Related antibodyAnti-NRCAM antibodyAnti-KIAA0343 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
