| Tissue Specificity | Isoform 4 is ubiquitous.it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients.whereas in epithelial cells, its expression is consistently stronger in asthma patients. |
| Function | G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. |
| Protein Name | Neuropeptide S ReceptorG-Protein Coupled Receptor 154G-Protein Coupled Receptor Pgr14G-Protein Coupled Receptor For Asthma Susceptibility |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-418555 |
| Cellular Localisation | Isoform 1: Cell MembraneMulti-Pass Membrane ProteinIsoform 3: Cell MembraneIsoform 4: Cell MembraneIsoform 2: CytoplasmIsoform 5: CytoplasmIsoform 6: CytoplasmIsoform 7: CytoplasmIsoform 9: Cytoplasm |
| Alternative Antibody Names | Anti-Neuropeptide S Receptor antibodyAnti-G-Protein Coupled Receptor 154 antibodyAnti-G-Protein Coupled Receptor Pgr14 antibodyAnti-G-Protein Coupled Receptor For Asthma Susceptibility antibodyAnti-NPSR1 antibodyAnti-GPR154 antibodyAnti-GPRA antibodyAnti-PGR14 antibody |
Information sourced from Uniprot.org
