| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NLGN1 (200-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NLGN1 |
| Gene ID: |
22871 |
| Uniprot ID: |
NLGN1_HUMAN |
| Immunogen Region: |
200-300 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human NLGN1 (NP_055747.1). |
| Immunogen Sequence: |
YGNVIVITVNYRLGVLGFLS TGDQAAKGNYGLLDLIQALR WTSENIGFFGGDPLRITVFG SGAGGSCVNLLTLSHYSEGN RWSNSTKGLFQRAIAQSGTA L |
| Tissue Specificity | Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells. |
| Function | Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. The protein is involved in nervous system development. |
| Protein Name | Neuroligin-1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPostsynaptic DensitySynaptic CleftSynaptic Cell MembraneEnriched In Synaptic Plasma Membranes And Clustered In Synaptic Clefts And Postsynaptic DensitiesColocalized With Dlg4/Psd-95 And Grin1/Nmdar1 |
| Alternative Antibody Names | Anti-Neuroligin-1 antibodyAnti-NLGN1 antibodyAnti-KIAA1070 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
