| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | NID2 |
| Gene ID: | 22795 |
| Uniprot ID: | NID2_HUMAN |
| Immunogen Region: | 900-1200 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 900-1200 of human NID2 (NP_031387.3). |
| Immunogen Sequence: | RCHPAATCYNTPGSFSCRCQ PGYYGDGFQCIPDSTSSLTP CEQQQRHAQAQYAYPGARFH IPQCDEQGNFLPLQCHGSTG FCWCVDPDGHEVPGTQTPPG STPPHCGPSPEPTQRPPTIC ERWRENLLEHYGGTPRDDQY VPQCDDLGHFIPLQCHGKSD FCWCVDKDGREVQGTRSQPG TTPACIPTVAPPMVRPTPRP DVTPPSVGTFLLYTQGQQIG YLPLNGTRLQKDAAKTLLS |
| Tissue Specificity | Detected in placenta (at protein level). Heart and bone. Less in pancreas, kidney and skeletal muscle. |
| Post Translational Modifications | Highly N-glycosylated. Highly O-glycosylated. Contains chondroitin sulfate which is attached at Ser-452 and at either Ser-358 or Ser-359. |
| Function | Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions. |
| Protein Name | Nidogen-2Nid-2Osteonidogen |
| Database Links | Reactome: R-HSA-3000157 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement Membrane |
| Alternative Antibody Names | Anti-Nidogen-2 antibodyAnti-Nid-2 antibodyAnti-Osteonidogen antibodyAnti-NID2 antibody |
Information sourced from Uniprot.org