| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NGRN |
| Gene ID: | 51335 |
| Uniprot ID: | NGRN_HUMAN |
| Immunogen Region: | 62-291 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 62-291 of human NGRN (NP_001028260.2). |
| Immunogen Sequence: | QAIRFQKIRRQMEAPGAPPR TLTWEAMEQIRYLHEEFPES WSVPRLAEGFDVSTDVIRRV LKSKFLPTLEQKLKQDQKVL KKAGLAHSLQHLRGSGNTSK LLPAGHSVSGSLLMPGHEAS SKDPNHSTALKVIESDTHRT NTPRRRKGRNKEIQDLEESF VPVAAPLGHPRELQKYSSDS ESPRGTGSGALPSGQKLEEL KAEEPDNFSSKVVQRGREFF DSNGNFLYRI |
| Tissue Specificity | Expressed at high levels in heart, brain and skeletal muscle. In brain, mainly expressed in neurons rather than glial cells. |
| Function | Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. |
| Protein Name | NeugrinMesenchymal Stem Cell Protein Dsc92Neurite Outgrowth-Associated ProteinSpinal Cord-Derived Protein Fi58g |
| Cellular Localisation | NucleusSecretedMitochondrion Membrane |
| Alternative Antibody Names | Anti-Neugrin antibodyAnti-Mesenchymal Stem Cell Protein Dsc92 antibodyAnti-Neurite Outgrowth-Associated Protein antibodyAnti-Spinal Cord-Derived Protein Fi58g antibodyAnti-NGRN antibodyAnti-FI58G antibodyAnti-HT020 antibody |
Information sourced from Uniprot.org