| Post Translational Modifications | Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production. |
| Function | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter.this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9. |
| Protein Name | Nfatc2-Interacting Protein45 Kda Nf-At-Interacting Protein45 Kda Nfat-Interacting ProteinNuclear Factor Of Activated T-Cells - Cytoplasmic 2-Interacting Protein |
| Cellular Localisation | NucleusCytoplasmTraf1 Is Associated With A Fraction Of Nfatc2ip In The Cytoplasm And Prevents Its Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Nfatc2-Interacting Protein antibodyAnti-45 Kda Nf-At-Interacting Protein antibodyAnti-45 Kda Nfat-Interacting Protein antibodyAnti-Nuclear Factor Of Activated T-Cells - Cytoplasmic 2-Interacting Protein antibodyAnti-NFATC2IP antibodyAnti-NIP45 antibody |
Information sourced from Uniprot.org
