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Anti-NFAT5 antibody [1D6] (STJ196652)

Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using NFAT5 mouse Monoclonal antibody diluted at 1:500.
Western blot analysis of 1) Hela Cell, 2) Mouse Brain, 3) Rat Brain Tissue lysate using NFAT5 mouse Monoclonal monoclonal antibody diluted at 1:2,000.

Anti-NFAT5 antibody [1D6] (STJ196652)

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STJ196652

£168.00 - £226.00

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Mouse
Applications:	IHC/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Nuclear factor of activated T-cells 5 is suitable for use in Immunohistochemistry and Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	1D6
Conjugation:	Unconjugated
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IHC-P 1:50-200 WB 1:1000-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	NFAT5
Gene ID:	10725
Uniprot ID:	NFAT5_HUMAN
Specificity:	This antibody detects endogenous levels of NFAT5 at Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from the human NFAT5

Post Translational Modifications	Phosphorylated. Phosphorylated at Thr-135 by CDK5 in response to osmotic stress.this phosphorylation mediates its rapid nuclear localization. Poly-ADP-ribosylated by PARP1 in response to DNA damage, promoting recruitment to sites of R-loop-associated DNA damage.
Function	Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-ACTAGTGGAAACATATAATCCAATGGTGACCGCT-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes.optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops.R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
Protein Name	Nuclear Factor Of Activated T-Cells 5 Nf-At5 T-Cell Transcription Factor Nfat5 Tonicity-Responsive Enhancer-Binding Protein Tone-Binding Protein Tonebp
Cellular Localisation	Nucleus Cytoplasm Chromosome Nuclear Distribution Increases Under Hypertonic Conditions Recruited To Sites Of R-Loop-Associated Dna Damage Following Poly-Adp-Ribosylation By Parp1
Alternative Antibody Names	Anti-Nuclear Factor Of Activated T-Cells 5 antibody Anti-Nf-At5 antibody Anti-T-Cell Transcription Factor Nfat5 antibody Anti-Tonicity-Responsive Enhancer-Binding Protein antibody Anti-Tone-Binding Protein antibody Anti-Tonebp antibody Anti-NFAT5 antibody Anti-KIAA0827 antibody Anti-TONEBP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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