| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NELFCD (40-182) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NELFCD |
| Gene ID: |
51497 |
| Uniprot ID: |
NELFD_HUMAN |
| Immunogen Region: |
40-182 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-182 of human NELFCD (NP_945327.3). |
| Immunogen Sequence: |
HKFSTRDYIMEPSIFNTLKR YFQAGGSPENVIQLLSENYT AVAQTVNLLAEWLIQTGVEP VQVQETVENHLKSLLIKHFD PRKADSIFTEEGETPAWLEQ MIAHTTWRDLFYKLAEAHPD CLMLNFTVKLISDAGYQGEI TSV |
| Tissue Specificity | Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas. |
| Function | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. |
| Protein Name | Negative Elongation Factor C/DNelf-C/DTh1-Like Protein |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167200Reactome: R-HSA-167238Reactome: R-HSA-167242Reactome: R-HSA-167243Reactome: R-HSA-167246Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-674695Reactome: R-HSA-6796648Reactome: R-HSA-75955 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Negative Elongation Factor C/D antibodyAnti-Nelf-C/D antibodyAnti-Th1-Like Protein antibodyAnti-NELFCD antibodyAnti-NELFD antibodyAnti-TH1 antibodyAnti-TH1L antibodyAnti-HSPC130 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
