Anti-NEK1 antibody (1-100) (STJ118500)

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STJ118500
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NEK1
Gene ID: 4750
Uniprot ID: NEK1_HUMAN
Immunogen Region: 1-100
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human NEK1 (NP_036356.1).
Immunogen Sequence: MEKYVRLQKIGEGSFGKAIL VKSTEDGRQYVIKEINISRM SSKEREESRREVAVLANMKH PNIVQYRESFEENGSLYIVM DYCEGGDLFKRINAQKGVLF
Tissue Specificity High fetal expression in the brain and kidney.
Function Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly.
Protein Name Serine/Threonine-Protein Kinase Nek1
Never In Mitosis A-Related Kinase 1
Nima-Related Protein Kinase 1
Renal Carcinoma Antigen Ny-Ren-55
Database Links Reactome: R-HSA-9861718
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Associated With The Pericentriolar Material
Localizes To Centrosome During Interphase And Mitosis
Translocated From Cytoplasm To Discrete Nuclear Foci At Sites Of Dna Damage
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase Nek1 antibody
Anti-Never In Mitosis A-Related Kinase 1 antibody
Anti-Nima-Related Protein Kinase 1 antibody
Anti-Renal Carcinoma Antigen Ny-Ren-55 antibody
Anti-NEK1 antibody
Anti-KIAA1901 antibody

Information sourced from Uniprot.org

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