| Post Translational Modifications | Cleavage of precursor form by UCHL3 or SENP8 is necessary for function. |
| Function | Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. |
| Protein Name | Ubiquitin-Like Protein Nedd8NeddylinNeural Precursor Cell Expressed Developmentally Down-Regulated Protein 8Nedd-8 |
| Database Links | Reactome: R-MMU-2173789Reactome: -MMU-5689603Reactome: -MMU-8856825Reactome: -MMU-8951664Reactome: -MMU-917937 |
| Cellular Localisation | NucleusMainly Nuclear |
| Alternative Antibody Names | Anti-Ubiquitin-Like Protein Nedd8 antibodyAnti-Neddylin antibodyAnti-Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8 antibodyAnti-Nedd-8 antibodyAnti-Nedd8 antibodyAnti-Nedd-8 antibody |
Information sourced from Uniprot.org
