| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NDNF |
| Gene ID: | 79625 |
| Uniprot ID: | NDNF_HUMAN |
| Immunogen Region: | 20-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human NDNF (NP_078850.3). |
| Immunogen Sequence: | QKLPTRDEELFQMQIRDKAF FHDSSVIPDGAEISSYLFRD TPKRYFFVVEEDNTPLSVTV TPCDAPLEWKLSLQELPEDR SGEGSGDLEPLEQQKQQIIN EEGTELFSYKGNDVEYFISS SSPSGLYQLDLLSTEKDTHF KVYATTTPESDQPYPELPYD PRVDVTSLGRTTVTLAWKPS PTASLLKQPIQYCVVINKEH NFKSLCAVEAKLSADDAFMM A |
| Tissue Specificity | Expressed in neurons along the gonadotropin-releasing hormone (GnRH) expressing neurons migratory route. |
| Post Translational Modifications | O-glycosylated.contains heparan sulfate and chondroitin sulfate. N-glycosylated. |
| Function | Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus. Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling. Also regulates extracellular matrix assembly and cell adhesiveness. Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms. |
| Protein Name | Protein Ndnf Neuron-Derived Neurotrophic Factor |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Protein Ndnf antibody Anti-Neuron-Derived Neurotrophic Factor antibody Anti-NDNF antibody Anti-C4orf31 antibody Anti-UNQ2748 antibody Anti-PRO6487 antibody |
Information sourced from Uniprot.org