| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
MYCN |
| Gene ID: |
4613 |
| Uniprot ID: |
MYCN_HUMAN |
| Immunogen Region: |
289-464 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 289-464 of human N-Myc/MYCN (NP_005369.2). |
| Immunogen Sequence: |
SNTKAVTTFTITVRPKNAAL GPGRAQSSELILKRCLPIHQ QHNYAAPSPYVESEDAPPQK KIKSEASPRPLKSVIPPKAK SLSPRNSDSEDSERRRNHNI LERQRRNDLRSSFLTLRDHV PELVKNEKAAKVVILKKATE YVHSLQAEEHQLLLEKEKLQ ARQQQLLKKIEHARTC |
| Tissue Specificity | Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level). |
| Post Translational Modifications | Phosphorylated by GSK3-beta which may promote its degradation. Phosphorylated by AURKA. |
| Function | Positively regulates the transcription of MYCNOS in neuroblastoma cells. |
| Protein Name | N-Myc Proto-Oncogene ProteinClass E Basic Helix-Loop-Helix Protein 37Bhlhe37 |
| Database Links | Reactome: R-HSA-201556Reactome: R-HSA-9839394 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-N-Myc Proto-Oncogene Protein antibodyAnti-Class E Basic Helix-Loop-Helix Protein 37 antibodyAnti-Bhlhe37 antibodyAnti-MYCN antibodyAnti-BHLHE37 antibodyAnti-NMYC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
