| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYO7A |
| Gene ID: | 4647 |
| Uniprot ID: | MYO7A_HUMAN |
| Immunogen Region: | 850-1150 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 850-1150 of human MYO7A (NP_000251.3). |
| Immunogen Sequence: | MIARRLHQRLRAEYLWRLEA EKMRLAEEEKLRKEMSAKKA KEEAERKHQERLAQLAREDA ERELKEKEAARRKKELLEQM ERARHEPVNHSDMVDKMFGF LGTSGGLPGQEGQAPSGFED LERGRREMVEEDLDAALPLP DEDEEDLSEYKFAKFAATYF QGTTTHSYTRRPLKQPLLYH DDEGDQLAALAVWITILRFM GDLPEPKYHTAMSDGSEKIP VMTKIYETLGKKTYKRELQ |
| Tissue Specificity | Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain. |
| Function | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. |
| Protein Name | Unconventional Myosin-Viia |
| Database Links | Reactome: R-HSA-2453902 Reactome: R-HSA-9662360 Reactome: R-HSA-9662361 |
| Cellular Localisation | Cytoplasm Cell Cortex Cytoskeleton Synapse In The Photoreceptor Cells Mainly Localized In The Inner And Base Of Outer Segments As Well As In The Synaptic Ending Region In Retinal Pigment Epithelial Cells Colocalizes With A Subset Of Melanosomes Displays Predominant Localization To Stress Fiber-Like Structures And Some Localization To Cytoplasmic Puncta Detected At The Tip Of Cochlear Hair Cell Stereocilia The Complex Formed By Myo7a Ush1c And Ush1g Colocalizes With F-Actin |
| Alternative Antibody Names | Anti-Unconventional Myosin-Viia antibody Anti-MYO7A antibody Anti-USH1B antibody |
Information sourced from Uniprot.org