| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYD88 |
| Gene ID: | 4615 |
| Uniprot ID: | MYD88_HUMAN |
| Immunogen Region: | 60-309 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-309 of human MyD88 (NP_002459.2). |
| Immunogen Sequence: | WTALAEEMDFEYLEIRQLET QADPTGRLLDAWQGRPGASV GRLLELLTKLGRDDVLLELG PSIEEDCQKYILKQQQEEAE KPLQVAAVDSSVPRTAELAG ITTLDDPLGHMPERFDAFIC YCPSDIQFVQEMIRQLEQTN YRLKLCVSDRDVLPGTCVWS IASELIEKRCRRMVVVVSDD YLQSKECDFQTKFALSLSPG AHQKRLIPIKYKAMKKEFPS ILRFITVCDYTNPCTKSWF |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Ubiquitinated.undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88. Deubiquitinated by USP3 that cleaves 'Lys-63'-linked ubiquitin chains leading to inhibition of MYD88-induced NF-kappa-B signaling. (Microbial infection) Ubiquitinated by human herpesvirus 8 (KSHV) protein RTA/ORF50, leading to proteasomal degradation ans suppression of TLR4 signaling pathway. |
| Function | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. |
| Protein Name | Myeloid Differentiation Primary Response Protein Myd88 |
| Database Links | Reactome: R-HSA-1236974 Reactome: R-HSA-1257604 Reactome: R-HSA-166058 Reactome: R-HSA-1810476 Reactome: R-HSA-209543 Reactome: R-HSA-3134963 Reactome: R-HSA-5602498 Reactome: R-HSA-5602680 Reactome: R-HSA-5603037 Reactome: R-HSA-5603041 Reactome: R-HSA-6811558 Reactome: R-HSA-9020702 Reactome: R-HSA-975110 Reactome: R-HSA-975138 Reactome: R-HSA-975155 Reactome: R-HSA-975871 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Myeloid Differentiation Primary Response Protein Myd88 antibody Anti-MYD88 antibody |
Information sourced from Uniprot.org