Immunohistochemistry analysis of MVP in paraffin-embedded Human colon tissue using MVP Rabbit polyclonal antibody (STJ24649) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M Tris-EDTA buffer (pH 9. 0) prior to immunohistochemistry staining.

Anti-MVP antibody (1-260) (STJ24649)

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STJ24649
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:1000-1:5000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MVP
Gene ID: 9961
Uniprot ID: MVP_HUMAN
Immunogen Region: 1-260
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MVP (NP_005106.2).
Immunogen Sequence: MATEEFIIRIPPYHYIHVLD QNSNVSRVEVGPKTYIRQDN ERVLFAPMRMVTVPPRHYCT VANPVSRDAQGLVLFDVTGQ VRLRHADLEIRLAQDPFPLY PGEVLEKDITPLQVVLPNTA LHLKALLDFEDKDGDKVVAG DEWLFEGPGTYIPRKEVEVV EIIQATIIRQNQALRLRARK ECWDRDGKERVTGEEWLVTT VGAYLPAVFEEVLDLVDAVI LTEKTALHLRARRNFRDFR
Tissue Specificity Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Post Translational Modifications Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11.
Function Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Protein Name Major Vault Protein
Mvp
Lung Resistance-Related Protein
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cytoplasm
Nucleus
Nuclear Pore Complex
Perinuclear Region
5% Found In The Nuclear Pore Complex
Translocates From The Nucleus To The Cytoplasm Upon Egf Treatment
Alternative Antibody Names Anti-Major Vault Protein antibody
Anti-Mvp antibody
Anti-Lung Resistance-Related Protein antibody
Anti-MVP antibody
Anti-LRP antibody

Information sourced from Uniprot.org

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