| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Crossover junction endonuclease MUS81 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MUS81 |
| Gene ID: | 80198 |
| Uniprot ID: | MUS81_HUMAN |
| Specificity: | This antibody detects endogenous levels of MUS81 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human MUS81 |
| Function | Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. Plays an essential role in mitosis for the processing of stalled or collapsed replication forks. |
| Protein Name | Crossover Junction Endonuclease Mus81 |
| Database Links | Reactome: R-HSA-5693568Reactome: R-HSA-6783310 |
| Cellular Localisation | NucleusNucleolusRecruited To Foci Of Dna Damage In S-Phase Cells |
| Alternative Antibody Names | Anti-Crossover Junction Endonuclease Mus81 antibodyAnti-MUS81 antibody |
Information sourced from Uniprot.org