Anti-MUM-1 antibody [EAU32] (STJ16101773)

Anti-MUM-1 antibody [EAU32] (STJ16101773)

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STJ16101773-1
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Multiple Myeloma Oncogene 1 is suitable for use in Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : EAU32
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Tissue culture supernatant with sodium azide
Concentration: >=263 mg/L
Dilution Range: IHC-P 1:100
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: Prokaryotic recombinant protein corresponding to 313 amino acids of the human multiple myeloma oncogene 1 (MUM-1) molecule.
Background The MUM-1 (multiple myeloma oncogene 1) gene was originally identified because of its involvement in the t (6:14) translocation observed in multiple myeloma, which causes the juxtaposition of the MUM-1 gene to the Ig heavy chain locus. MUM-1 is expressed in late plasma cell directed stages of B cell differentiation and in activated T cells, suggesting that MUM-1 may serve as a marker for lympho-hemopoietic neoplasms derived from these cells. The morphologic spectrum of MUM-1 expressing cells has been found to range from that of a centrocyte to that of a plasmablast/plasma cell. Consequently the histogenic value of MUM-1 may be to provide a marker to aid in the identification of the transition from BCL-6 positive (germinal center B cells) to CD138 positive (immunoblasts and plasma cells).

Information sourced from Uniprot.org

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