| Tissue Specificity | Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme. |
| Function | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. |
| Protein Name | Protein Lyric3d3/LyricAstrocyte Elevated Gene-1 ProteinAeg-1Lysine-Rich Ceacam1 Co-Isolated ProteinMetadherinMetastasis Adhesion Protein |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinNucleus MembraneCell JunctionTight JunctionNucleusNucleolusCytoplasmPerinuclear RegionIn Epithelial CellsRecruited To Tight Junctions (Tj) During The Maturation Of The Tj ComplexesA Nucleolar Staining May Be Due To Nuclear Targeting Of An Isoform Lacking The Transmembrane DomainTnf-Alpha Causes Translocation From The Cytoplasm To The Nucleus |
| Alternative Antibody Names | Anti-Protein Lyric antibodyAnti-3d3/Lyric antibodyAnti-Astrocyte Elevated Gene-1 Protein antibodyAnti-Aeg-1 antibodyAnti-Lysine-Rich Ceacam1 Co-Isolated Protein antibodyAnti-Metadherin antibodyAnti-Metastasis Adhesion Protein antibodyAnti-MTDH antibodyAnti-AEG1 antibodyAnti-LYRIC antibody |
Information sourced from Uniprot.org
