Anti-MSL1 antibody (210-300) (STJ119888)

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STJ119888
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MSL1
Gene ID: 339287
Uniprot ID: MSL1_HUMAN
Immunogen Region: 210-300
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 210-300 of human MSL1 (NP_001012241).
Immunogen Sequence: LAVPSWRDHSVEPLRDPNPS DLLENLDDSVFSKRHAKLEL DEKRRKRWDIQRIREQRILQ RLQLRMYKKKGIQESEPEVT SFFPEPDDVES
Post Translational Modifications Sumoylated with SUMO1.
Function Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. X up-regulation is required to compensate for autosomal biallelic expression. The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA. Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Protein Name Male-Specific Lethal 1 Homolog
Msl-1
Male-Specific Lethal 1-Like 1
Msl1-Like 1
Male-Specific Lethal-1 Homolog 1
Database Links Reactome: R-HSA-3214847
Cellular Localisation Nucleus
Nucleoplasm
Nucleus Speckle
Alternative Antibody Names Anti-Male-Specific Lethal 1 Homolog antibody
Anti-Msl-1 antibody
Anti-Male-Specific Lethal 1-Like 1 antibody
Anti-Msl1-Like 1 antibody
Anti-Male-Specific Lethal-1 Homolog 1 antibody
Anti-MSL1 antibody
Anti-MSL1L1 antibody

Information sourced from Uniprot.org