| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MSL1 (210-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MSL1 |
| Gene ID: |
339287 |
| Uniprot ID: |
MSL1_HUMAN |
| Immunogen Region: |
210-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 210-300 of human MSL1 (NP_001012241). |
| Immunogen Sequence: |
LAVPSWRDHSVEPLRDPNPS DLLENLDDSVFSKRHAKLEL DEKRRKRWDIQRIREQRILQ RLQLRMYKKKGIQESEPEVT SFFPEPDDVES |
| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. |
| Protein Name | Male-Specific Lethal 1 HomologMsl-1Male-Specific Lethal 1-Like 1Msl1-Like 1Male-Specific Lethal-1 Homolog 1 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | NucleusNucleoplasmNucleus Speckle |
| Alternative Antibody Names | Anti-Male-Specific Lethal 1 Homolog antibodyAnti-Msl-1 antibodyAnti-Male-Specific Lethal 1-Like 1 antibodyAnti-Msl1-Like 1 antibodyAnti-Male-Specific Lethal-1 Homolog 1 antibodyAnti-MSL1 antibodyAnti-MSL1L1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
