| Host: |
Rat |
| Applications: |
ICC/IHC-F/FC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rat monoclonal antibody anti-MRP6 is suitable for use in Immunocytochemistry, Immunohistochemistry, Flow Cytometry and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
M6II-21 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
supernatant with 1% BSA and 0.1% sodium azide |
| Concentration: |
100 ug/mL |
| Dilution Range: |
ICCIHC-F 1:20-1:50FCWB 1:20-1:50 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Tissue Specificity | Expressed in kidney and liver. Very low expression in other tissues. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules. |
| Post Translational Modifications | Glycosylated. |
| Function | Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 6Anthracycline Resistance-Associated ProteinMulti-Specific Organic Anion Transporter EMoat-EMultidrug Resistance-Associated Protein 6 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5690338 |
| Cellular Localisation | Basal Cell MembraneMulti-Pass Membrane ProteinLocalized To The Basal Membrane Of Sertoli CellsIsoform 1: Basolateral Cell MembraneIsoform 2: Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 6 antibodyAnti-Anthracycline Resistance-Associated Protein antibodyAnti-Multi-Specific Organic Anion Transporter E antibodyAnti-Moat-E antibodyAnti-Multidrug Resistance-Associated Protein 6 antibodyAnti-ABCC6 antibodyAnti-ARA antibodyAnti-MRP6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
