| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCC2 |
| Gene ID: | 1244 |
| Uniprot ID: | MRP2_HUMAN |
| Immunogen Region: | 1446-1545 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1446-1545 of human MRP2/ABCC2 (Q92887). |
| Immunogen Sequence: | CLGRALLRKSKILVLDEATA AVDLETDNLIQTTIQNEFAH CTVITIAHRLHTIMDSDKVM VLDNGKIIECGSPEELLQIP GPFYFMAKEAGIENVNSTKF |
| Tissue Specificity | Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver. Expressed in small intestine. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors. Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 2 Canalicular Multidrug Resistance Protein Canalicular Multispecific Organic Anion Transporter 1 Multidrug Resistance-Associated Protein 2 |
| Database Links | Reactome: R-HSA-189483 Reactome: R-HSA-382556 Reactome: R-HSA-5679001 Reactome: R-HSA-9749641 Reactome: R-HSA-9753281 Reactome: R-HSA-9754706 |
| Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Localized To The Apical Membrane Of Enterocytes |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 2 antibody Anti-Canalicular Multidrug Resistance Protein antibody Anti-Canalicular Multispecific Organic Anion Transporter 1 antibody Anti-Multidrug Resistance-Associated Protein 2 antibody Anti-ABCC2 antibody Anti-CMOAT antibody Anti-CMOAT1 antibody Anti-CMRP antibody Anti-MRP2 antibody |
Information sourced from Uniprot.org