• Western blot analysis of lysates from HeLa and RAW264.7 cells, using MOV10L1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from HT-29 cells using MOV10L1 antibody.
  • Western blot analysis of various cells using MOV10L1 Polyclonal Antibody diluted at 1：500

Anti-MOV10L1 antibody (318-367) (STJ94184)

SKU:
STJ94184

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RNA helicase Mov10l1 (318-367) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MOV10L1
Gene ID: 54456
Uniprot ID: M10L1_HUMAN
Immunogen Region: 318-367
Specificity: MOV10L1 Polyclonal Antibody detects endogenous levels of MOV10L1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human MOV10L1. AA range:318-367
Tissue Specificity Isoform 1: Specifically expressed in testis.
Function ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.
Protein Name Rna Helicase Mov10l1
Moloney Leukemia Virus 10-Like Protein 1
Mov10-Like Protein 1
Database Links Reactome: R-HSA-5601884
Cellular Localisation Cytoplasm
Component Of The Meiotic Nuage
Also Named P Granule
A Germ-Cell-Specific Organelle Required To Repress Transposon Activity During Meiosis
Alternative Antibody Names Anti-Rna Helicase Mov10l1 antibody
Anti-Moloney Leukemia Virus 10-Like Protein 1 antibody
Anti-Mov10-Like Protein 1 antibody
Anti-MOV10L1 antibody

Information sourced from Uniprot.org

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