| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MMADHC (1-296) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MMADHC |
| Gene ID: |
27249 |
| Uniprot ID: |
MMAD_HUMAN |
| Immunogen Region: |
1-296 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-296 of human MMADHC (NP_056517.1). |
| Immunogen Sequence: |
MANVLCNRARLVSYLPGFCS LVKRVVNPKAFSTAGSSGSD ESHVAAAPPDICSRTVWPDE TMGPFGPQDQRFQLPGNIGF DCHLNGTASQKKSLVHKTLP DVLAEPLSSERHEFVMAQYV NEFQGNDAPVEQEINSAETY FESARVECAIQTCPELLRKD FESLFPEVANGKLMILTVTQ KTKNDMTVWSEEVEIEREVL LEKFINGAKEICYALRAEGY WADFIDPSSGLAFFGPYTN |
| Tissue Specificity | Widely expressed at high levels. |
| Function | Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. |
| Protein Name | Cobalamin Trafficking Protein CbldCbldMethylmalonic Aciduria And Homocystinuria Type D Protein - Mitochondrial |
| Database Links | Reactome: R-HSA-3359473Reactome: R-HSA-9759218 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Cobalamin Trafficking Protein Cbld antibodyAnti-Cbld antibodyAnti-Methylmalonic Aciduria And Homocystinuria Type D Protein - Mitochondrial antibodyAnti-MMADHC antibodyAnti-C2orf25 antibodyAnti-CL25022 antibodyAnti-HSPC161 antibodyAnti-My011 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
