Western blot analysis of MLF1 Antibody. The lane on the right is blocked with the MLF1 peptide.

Anti-MLF1 antibody (130-210) (STJ94144)

SKU:
STJ94144
£48.00 - £252.00
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Myeloid leukemia factor 1 (130-210) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MLF1
Gene ID: 4291
Uniprot ID: MLF1_HUMAN
Immunogen Region: 130-210
Specificity: MLF1 Polyclonal Antibody detects endogenous levels of MLF1 protein.
Immunogen: Synthesized peptide derived from MLF1. at AA range: 130-210
Tissue Specificity Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
Post Translational Modifications Phosphorylation is required for binding to YWHAZ.
Function Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Protein Name Myeloid Leukemia Factor 1
Myelodysplasia-Myeloid Leukemia Factor 1
Cellular Localisation Cytoplasm
Nucleus
Cell Projection
Cilium
Cytoskeleton
Cilium Basal Body
Shuttles Between The Cytoplasm And Nucleus
Alternative Antibody Names Anti-Myeloid Leukemia Factor 1 antibody
Anti-Myelodysplasia-Myeloid Leukemia Factor 1 antibody
Anti-MLF1 antibody

Information sourced from Uniprot.org

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