Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | Dusp1 |
Gene ID: | 19252 |
Uniprot ID: | DUS1_MOUSE |
Immunogen Region: | 1-172 aa |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of mouse MKP1. (NP_038670.1). |
Immunogen Sequence: | MVMEVGILDAGGLRALLREG AAQCLLLDCRSFFAFNAGHI AGSVNVRFSTIVRRRAKGAM GLEHIVPNAELRGRLLAGAY HAVVLLDERSASLDGAKRDG TLALAAGALCREARSTQVFF LQGGYEAFSASCPELCSKQS TPTGLSLPLSTSVPDSAESG CSSCSTPLYDQG |
Post Translational Modifications | Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation. |
Function | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. |
Protein Name | Dual Specificity Protein Phosphatase 1Mitogen-Activated Protein Kinase Phosphatase 1Map Kinase Phosphatase 1Mkp-1Protein-Tyrosine Phosphatase 3ch134Protein-Tyrosine Phosphatase Erp |
Database Links | Reactome: R-MMU-112409Reactome: -MMU-5675221 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 1 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 1 antibodyAnti-Map Kinase Phosphatase 1 antibodyAnti-Mkp-1 antibodyAnti-Protein-Tyrosine Phosphatase 3ch134 antibodyAnti-Protein-Tyrosine Phosphatase Erp antibodyAnti-Dusp1 antibodyAnti-3ch134 antibodyAnti-Mkp1 antibodyAnti-Ptpn10 antibodyAnti-Ptpn16 antibody |
Information sourced from Uniprot.org