| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MGST2 |
| Gene ID: | 4258 |
| Uniprot ID: | MGST2_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human MGST2 (NP_002404.1). |
| Immunogen Sequence: | FRAQQNCVEFYPIFIITLWM AGWYFNQVFATCLGLVYIYG RHLYFWGYSEAAKKRITGFR LSLGILALLTLLGALGIANS FLDEYLDLNIAKKLRRQF |
| Tissue Specificity | Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow. Abundantly expressed in human umbilical vein endothelial cells (at protein level). |
| Function | Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells. |
| Protein Name | Microsomal Glutathione S-Transferase 2 Microsomal Gst-2 Glutathione Peroxidase Mgst2 Leukotriene C4 Synthase Mgst2 Microsomal Glutathione S-Transferase Ii Microsomal Gst-Ii |
| Database Links | Reactome: R-HSA-156590 Reactome: R-HSA-5423646 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Microsome Membrane |
| Alternative Antibody Names | Anti-Microsomal Glutathione S-Transferase 2 antibody Anti-Microsomal Gst-2 antibody Anti-Glutathione Peroxidase Mgst2 antibody Anti-Leukotriene C4 Synthase Mgst2 antibody Anti-Microsomal Glutathione S-Transferase Ii antibody Anti-Microsomal Gst-Ii antibody Anti-MGST2 antibody Anti-GST2 antibody |
Information sourced from Uniprot.org