Western blot analysis of extracts of various cell lines, using MESDC2 antibody (STJ115867) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-MESDC2 antibody (1-234) (STJ115867)

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STJ115867
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MESD
Gene ID: 23184
Uniprot ID: MESD_HUMAN
Immunogen Region: 1-234
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human MESDC2 (NP_055969.1).
Immunogen Sequence: MAASRWARKAVVLLCASDLL LLLLLLPPPGSCAAEGSPGT PDESTPPPRKKKKDIRDYND ADMARLLEQWEKDDDIEEGD LPEHKRPSAPVDFSKIDPSK PESILKMTKKGKTLMMFVTV SGSPTEKETEEITSLWQGSL FNANYDVQRFIVGSDRAIFM LRDGSYAWEIKDFLVGQDRC ADVTLEGQVYPGKGGGSKEK NKTKQDKGKKKKEGDLKSRS SKEENRAGNKREDL
Function Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
Protein Name Lrp Chaperone Mesd
Ldlr Chaperone Mesd
Mesoderm Development Lrp Chaperone Mesd
Mesoderm Development Candidate 2
Mesoderm Development Protein
Renal Carcinoma Antigen Ny-Ren-61
Cellular Localisation Endoplasmic Reticulum
Released From Apoptotic Cells And Shed Photoreceptor Outer Segments
Alternative Antibody Names Anti-Lrp Chaperone Mesd antibody
Anti-Ldlr Chaperone Mesd antibody
Anti-Mesoderm Development Lrp Chaperone Mesd antibody
Anti-Mesoderm Development Candidate 2 antibody
Anti-Mesoderm Development Protein antibody
Anti-Renal Carcinoma Antigen Ny-Ren-61 antibody
Anti-MESD antibody
Anti-KIAA0081 antibody
Anti-MESDC2 antibody
Anti-MESDM antibody
Anti-UNQ1911 antibody
Anti-PRO4369 antibody

Information sourced from Uniprot.org

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