Anti-MERS-CoV Spike RBD antibody (18-725) (STJ11103388)

SKU:
STJ11103388
£112.50 - £524.50
Free Shipping
Processing The item has been added

Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: MERS-CoV
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunogen Region: 18-725
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 18-725 of coronavirus Spike RBD (YP_009047204.1).
Immunogen Sequence: YVDVGPDSVKSACIEVDIQQ TFFDKTWPRPIDVSKADGII YPQGRTYSNITITYQGLFPY QGDHGDMYVYSAGHATGTTP QKLFVANYSQDVKQFANGFV VRIGAAANSTGTVIISPSTS ATIRKIYPAFMLGSSVGNFS DGKMGRFFNHTLVLLPDGCG TLLRAFYCILEPRSGNHCPA GNSYTSFATYHTPATDCSDG NYNRNASLNSFKEYFNLRNC TFMYTYNITEDEILEWFGI
Background It s been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD) , which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Information sourced from Uniprot.org