| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MCM3AP (250-550) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MCM3AP |
| Gene ID: |
8888 |
| Uniprot ID: |
GANP_HUMAN |
| Immunogen Region: |
250-550 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 250-550 of human MCM3AP (NP_003897.2). |
| Immunogen Sequence: |
SSFPVSSAVLGEPFQASKAG VRQGCEEAVSQVEPLPSLMK GLKRKEDQDRSPRRHGHEPA EDSDPLSRGDHPPDKRPVRL NRPRGGTLFGRTIQDVFKSN KEVGRLGNKEAKKETGFVES AESDHMAIPGGNQSVLAPSR IPGVNKEEETESREKKEDSL RGTPARQSNRSESTDSLGGL SPSEVTAIQCKNIPDYLNDR TILENHFGKIAKVQRIFTRR SKKLAVVHFFDHASAALAR |
| Tissue Specificity | Widely expressed. Up-regulated in germinal center B-cells in tonsils (at protein level). |
| Function | Isoform GANP: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. Isoform MCM3AP: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. |
| Protein Name | Germinal-Center Associated Nuclear ProteinGanp80 Kda Mcm3-Associated ProteinMcm3 Acetylating ProteinMcm3apMcm3 Acetyltransferase |
| Cellular Localisation | Isoform Ganp: Nucleus EnvelopeNucleusNuclear Pore ComplexNucleoplasmChromosomePredominantly Located At The Nuclear EnvelopeFacing The Nucleus InteriorLocalization At The Nuclear Pore Complex Requires Nup153Tpr And Alyref/AlyAlso Found Associated With ChromatinIn B-CellsTargeted To The Immunoglobulin Variable Region GenesIsoform Mcm3ap: CytoplasmTranslocates Into The Nucleus In The Presence Of Mcm3Associates With Chromatin Possibly Through Interaction With Mcm3 |
| Alternative Antibody Names | Anti-Germinal-Center Associated Nuclear Protein antibodyAnti-Ganp antibodyAnti-80 Kda Mcm3-Associated Protein antibodyAnti-Mcm3 Acetylating Protein antibodyAnti-Mcm3ap antibodyAnti-Mcm3 Acetyltransferase antibodyAnti-MCM3AP antibodyAnti-GANP antibodyAnti-KIAA0572 antibodyAnti-MAP80 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
