| Post Translational Modifications | LC1 is generated from MAP1B by proteolytic processing. S-nitrosylation at Cys-2464 enhances interaction with microtubules, and may act as an effector modification for neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction. |
| Function | Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. |
| Protein Name | Microtubule-Associated Protein 1bMap-1b Cleaved Into - Map1b Heavy Chain - Map1 Light Chain Lc1 |
| Database Links | Reactome: R-HSA-9833110 |
| Cellular Localisation | CytoplasmCytoskeletonSynapseCell ProjectionDendritic SpineColocalizes With Dapk1 In The Microtubules And Cortical Actin FibersMap1 Light Chain Lc1: Cytoplasm |
| Alternative Antibody Names | Anti-Microtubule-Associated Protein 1b antibodyAnti-Map-1b Cleaved Into - Map1b Heavy Chain - Map1 Light Chain Lc1 antibodyAnti-MAP1B antibody |
Information sourced from Uniprot.org
