| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAN1B1 (1-290) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAN1B1 |
| Gene ID: |
11253 |
| Uniprot ID: |
MA1B1_HUMAN |
| Immunogen Region: |
1-290 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human MAN1B1 (NP_057303.2). |
| Immunogen Sequence: |
MAACEGRRSGALGSSQSDFL TPPVGGAPWAVATTVVMYPP PPPPPHRDFISVTLSFGENY DNSKSWRRRSCWRKWKQLSR LQRNMILFLLAFLLFCGLLF YINLADHWKALAFRLEEEQK MRPEIAGLKPANPPVLPAPQ KADTDPENLPEISSQKTQRH IQRGPPHLQIRPPSQDLKDG TQEEATKRQEAPVDPRPEGD PQRTVISWRGAVIEPEQGTE LPSRRAEVPTKPPLPPART |
| Tissue Specificity | Widely expressed. |
| Function | Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). |
| Protein Name | Endoplasmic Reticulum Mannosyl-Oligosaccharide 1 -2-Alpha-MannosidaseEr Alpha-1 -2-MannosidaseEr Mannosidase 1Erman1Man9glcnac2-Specific-Processing Alpha-MannosidaseMannosidase Alpha Class 1b Member 1 |
| Database Links | Reactome: R-HSA-4793950Reactome: R-HSA-901032Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Endoplasmic Reticulum Mannosyl-Oligosaccharide 1 -2-Alpha-Mannosidase antibodyAnti-Er Alpha-1 -2-Mannosidase antibodyAnti-Er Mannosidase 1 antibodyAnti-Erman1 antibodyAnti-Man9glcnac2-Specific-Processing Alpha-Mannosidase antibodyAnti-Mannosidase Alpha Class 1b Member 1 antibodyAnti-MAN1B1 antibodyAnti-UNQ747 antibodyAnti-PRO1477 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
