Anti-MadCAM-1 antibody [314G8] (STJ16100465)

SKU:
STJ16100465-1

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Host: Mouse
Applications: IHC-F/ELISA/IHC-P/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-MadCAM-1 is suitable for use in Immunohistochemistry, ELISA, Immunohistochemistry and Western Blot research applications.
Clonality: Monoclonal
Clone ID: 314G8
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS with 0.1% BSA and 0.02% sodium azide
Concentration: 100 ug/mL
Dilution Range: WB 1:50
FC 1:50
IHC 1:50
ELISA 1:50
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: MADCAM1
Gene ID: 8174
Uniprot ID: MADCA_HUMAN
Tissue Specificity Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
Post Translational Modifications The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
Function Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Protein Name Mucosal Addressin Cell Adhesion Molecule 1
Madcam-1
Hmadcam-1
Database Links Reactome: R-HSA-198933 Q13477-1
Reactome: R-HSA-216083 Q13477-1
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Mucosal Addressin Cell Adhesion Molecule 1 antibody
Anti-Madcam-1 antibody
Anti-Hmadcam-1 antibody
Anti-MADCAM1 antibody

Information sourced from Uniprot.org

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