| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LTC4S |
| Gene ID: |
4056 |
| Uniprot ID: |
LTC4S_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human LTC4S (NP_665874.1). |
| Immunogen Sequence: |
YRAQVNCSEYFPLFLATLWV AGIFFHEGAAALCGLVYLFA RLRYFQGYARSAQLRLAPLY ASARALWLLVALAALGLLAH FLPAALRAALLGRLRTLLPW A |
| Tissue Specificity | Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. |
| Post Translational Modifications | Phosphorylation at Ser-36 by RPS6KB1 inhibits the leukotriene-C4 synthase activity. |
| Function | Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions. |
| Protein Name | Leukotriene C4 SynthaseLtc4 SynthaseGlutathione S-Transferase Ltc4Leukotriene-C(4 SynthaseLeukotriene-C4 Synthase |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142691Reactome: R-HSA-2142700Reactome: R-HSA-9026762Reactome: R-HSA-9026766 |
| Cellular Localisation | Nucleus Outer MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneNucleus Membrane |
| Alternative Antibody Names | Anti-Leukotriene C4 Synthase antibodyAnti-Ltc4 Synthase antibodyAnti-Glutathione S-Transferase Ltc4 antibodyAnti-Leukotriene-C(4 Synthase antibodyAnti-Leukotriene-C4 Synthase antibodyAnti-LTC4S antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
