| Tissue Specificity | Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. |
| Post Translational Modifications | Phosphorylation at Ser-36 by RPS6KB1 inhibits the leukotriene-C4 synthase activity. |
| Function | Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions. |
| Protein Name | Leukotriene C4 SynthaseLtc4 SynthaseGlutathione S-Transferase Ltc4Leukotriene-C(4 SynthaseLeukotriene-C4 Synthase |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142691Reactome: R-HSA-2142700Reactome: R-HSA-9026762Reactome: R-HSA-9026766 |
| Cellular Localisation | Nucleus Outer MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneNucleus Membrane |
| Alternative Antibody Names | Anti-Leukotriene C4 Synthase antibodyAnti-Ltc4 Synthase antibodyAnti-Glutathione S-Transferase Ltc4 antibodyAnti-Leukotriene-C(4 Synthase antibodyAnti-Leukotriene-C4 Synthase antibodyAnti-LTC4S antibody |
Information sourced from Uniprot.org
