| Tissue Specificity | Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue. |
| Post Translational Modifications | Ubiquitination promoted by PHF23 leads to proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy). |
| Protein Name | E3 Ubiquitin-Protein Ligase Lrsam1Leucine-Rich Repeat And Sterile Alpha Motif-Containing Protein 1Ring-Type E3 Ubiquitin Transferase Lrsam1Tsg101-Associated LigaseHtal |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmDisplays A Punctuate Distribution And Localizes To A Submembranal RingLocalizes To Intracellular Bacterial Pathogens |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Lrsam1 antibodyAnti-Leucine-Rich Repeat And Sterile Alpha Motif-Containing Protein 1 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Lrsam1 antibodyAnti-Tsg101-Associated Ligase antibodyAnti-Htal antibodyAnti-LRSAM1 antibodyAnti-TAL antibodyAnti-UNQ6496 antibodyAnti-PRO21356 antibody |
Information sourced from Uniprot.org
