| Function | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. |
| Protein Name | Leucine-Rich Repeat Flightless-Interacting Protein 1Lrr Flii-Interacting Protein 1Gc-Binding Factor 2Tar Rna-Interacting Protein |
| Database Links | Reactome: R-HSA-1839117Reactome: R-HSA-3134973Reactome: R-HSA-5655302 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Flightless-Interacting Protein 1 antibodyAnti-Lrr Flii-Interacting Protein 1 antibodyAnti-Gc-Binding Factor 2 antibodyAnti-Tar Rna-Interacting Protein antibodyAnti-LRRFIP1 antibodyAnti-GCF2 antibodyAnti-TRIP antibody |
Information sourced from Uniprot.org
