• Western blot analysis of extracts of various cell lines, using LRRFIP1 antibody (STJ118197) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-LRRFIP1 antibody (589-808) (STJ118197)

SKU:
STJ118197

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-LRRFIP1 (589-808) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: LRRFIP1
Gene ID: 9208
Uniprot ID: LRRF1_HUMAN
Immunogen Region: 589-808
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 589-808 of human LRRFIP1 (NP_001131024.1).
Immunogen Sequence: KDVKKELTYQNTDLSEIKEE EQVKSTDRKSAVEAQNEVTE NPKQKIAAESSENVDCPENP KIKLDGKLDQEGDDVQTAAE EVLADGDTLDFEDDTVQSSG PRAGGEELDEGVAKDNAKID GATQSSPAEPKSEDADRCTL PEHESPSQDISDACEAESTE RCEMSEHPSQTVRKALDSNS LENDDLSAPGREPGHFNPES REDTRGGNEKGKSKEDCTMS
Tissue Specificity Ubiquitously expressed.
Function Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Protein Name Leucine-Rich Repeat Flightless-Interacting Protein 1
Lrr Flii-Interacting Protein 1
Gc-Binding Factor 2
Tar Rna-Interacting Protein
Database Links Reactome: R-HSA-1839117
Reactome: R-HSA-3134973
Reactome: R-HSA-5655302
Cellular Localisation Nucleus
Cytoplasm
Alternative Antibody Names Anti-Leucine-Rich Repeat Flightless-Interacting Protein 1 antibody
Anti-Lrr Flii-Interacting Protein 1 antibody
Anti-Gc-Binding Factor 2 antibody
Anti-Tar Rna-Interacting Protein antibody
Anti-LRRFIP1 antibody
Anti-GCF2 antibody
Anti-TRIP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance